Transcriptomic and Proteomic Tools in the Study of Hg Toxicity: What Is Missing?

Transcriptomic and Proteomic Tools in the Study of Hg Toxicity: What Is Missing?

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Mercury is a hazardous substance that has unique neurodevelopmental toxic effects in humans.However, the precise sequence of molecular events that culminate in Hg-induced neuropathology is still unknown.Though the omics studies have been generating an enormous amount of new data about Hg toxicity, our ability to interpret such a large quantity of information is baseball scoreboards for sale still limited.In this opinion article, we will reinforce the necessity of new high throughput and accurate analytical proteomic methodologies, especially, thiol and selenol-proteome.

Overall, we posit that improvements in thiol- and selenol-proteomic analyses will be pivotal here in identifying the primary cellular targets of Hg.However, a better understanding of the complex cascades and molecular pathways involved in its toxicity will require extensive complementary studies in more complex systems.